NFKB1 and pulmonary arterial hypertension: In the rat sugen-hypoxia PAH model, administration of the NF-κB inhibitor pyrrolidine dithiocarbamate (PDTC) also reduced apoptosis of PASMC and obliteration of these vessels, promoted immune regulation (e.g. by increasing perivascular T cells and reducing T lymphocytes and CD45RA+ B lymphocytes, while preserving right ventricular function [47]).