IGF1 and colorectal carcinoma: This study builds on a number of previous studies on SNPs in genes related to the IGF pathway and CRC risk6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 27, 28 and provides further evidence for the involvement of the IGF pathway in colorectal tumorigenesis.