IGF1 and colorectal carcinoma: Indeed, genetic variants in genes encoding for IGF-related factors have been associated with CRC risk in several studies6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, but integration of genetic information from across genes in the IGF pathway is lacking.