With respect to the IGF1 19-CA repeat polymorphism, we observed a reduced CRC risk to be associated with variant alleles in women when using the classical categorization by Rosen et al. 44 A risk reduction at all subsites was present in women with less than 38 repeats but not in women with more than 38 repeats on both chromosomes together when we distinguished between individuals carrying less or more than 38 repeats. The gene discussed is IGF1; the disease is colorectal carcinoma.