Although cervical and liver cells are not the major known cells to breakdown triglyceride to release glycerol and the cells used in our study may not reflect physiological condition, both HeLa and hepatoma cells had used to examine the effect of HIF-2α or pigment epithelium-derived factor on triglyceride degradation pathway [51, 52]. The gene discussed is EPAS1; the disease is hepatocellular carcinoma.