In addition, we identified that hsa-miR-34c-5p and hsa-miR-34b-5p cooperatively target neuronatin (NNAT; rs1780705) and proteosome subunit beta, type 5 (PSMB5; rs10137082)–two mRNA hub genes with significant eQTLs that were also associated with AD (p< 10−3) in the COGA sample. Here, PSMB5 is linked to Alzheimer disease.