AP1S1, a clathrin-related protein involved in membrane trafficking and endocytosis, as well as the causal gene for MENDIK (mental retardation, enteropathy, deafness, neuropathy, ichthyosis and keratoderma) syndrome, was differentially expressed in the PFC of chronic alcoholics [9, 84]. This evidence concerns the gene AP1S1 and Abnormal intestine morphology.