Shared a priori gene set enrichment between the glial cell-associated modules was predominantly between Mgreen, Mpink and Msalmon, totaling 18 gene sets, with genes involved in cytokine/immune signaling, cell surface interactions, and cell signaling pathways (JAK/STAT, RhoA and TGF-β), which were upregulated in AD cases. The gene discussed is RHOA; the disease is Alzheimer disease.