Among the enriched eQTL sets, the most significant GWAS signals in COGA at p≤10−3 were: 1) rs1780705 for neuronatin (NNAT), a mRNA hub gene in Myellow, associated with AD at p = 2.2x10-4, 2) rs13392737 for a long non-coding RNA (PKI55), a mRNA hub gene in Mturquoise, associated with AD at p = 1.6x10-4 and 3) rs4243820 for replication protein A2, 32kDa (RPA2), a mRNA hub gene in Mturquoise, associated with an AD at p = 4.1x10-4[58, 59]. The gene discussed is RPA2; the disease is Alzheimer disease.