In addition, it has been shown that Ripk3 mRNA is present in methionine-choline-deficient diet, human non-alcoholic steatohepatitis in liver, and hepatocarcinogenesis16, 52, 53, 54, implicating that there may be little role in healthy liver, but RIPK3 function can be induced in diseased liver. The gene discussed is RIPK3; the disease is metabolic dysfunction-associated steatohepatitis.