In contrast, while the total numbers of spleen cells were reduced at 72 hours post-infection, including CCR2+Ly6C+ (monocytes), CD11c+ MHC Class II+ (dendritic cells), and CD11b+Ly6G+ (neutrophils), the relative proportions of these cells stayed similar to those observed in control animals while F4/80+CD80+MHC-II+ mononuclear phagocytes were disproportionally decreased relative to other cell populations (Fig 4B and 4C). The gene discussed is CD80; the disease is infection.