CALCA and infection: Based on the changes in serum cytokine and chemokine profiles of animals sedated with propofol, particularly the significant increase in the monocyte recruitment chemokine MCP-1 (CCL2) and the neutrophil chemoattractant KC (CXCL1) and the early increase in bacterial burdens at 96 hours, we determined if drug treatment altered the presence of innate immune effector cells at sites of infection.