BCL2 and ischemia: Before the onset of simulated ischemia, mRNA expression of the anti-apoptotic factors BCL-XL and BAG1 was similar in preconditioned and non-preconditioned CB-MSCs, whereas BCL-2 expression was suppressed by HP (relative expression: 1.6±0.1×10−4 vs. non-HP 3.6±0.3×10−4; P < 0.01) (Fig 4C).