PLOD3 and recessive dystrophic epidermolysis bullosa: To investigate a link between the altered dermal architecture in RDEB [28,29] and a reduction of the essential collagen modifying enzyme lysyl hydroxylase 3 (LH3), we followed up our previous gene expression profiling of cultured keratinocytes [30] that shows PLOD3 (encoding LH3) is significantly reduced in RDEB (S1 Table).