NOTCH3 and cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1: It has been shown that Notch3-null mice is defected in the vascular development [16], and Notch3 mutations are responsible for heritable cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) syndrome with alterations in vascular smooth muscle cells (VSMCs) [22].