It has been shown that Notch3-null mice is defected in the vascular development [16], and Notch3 mutations are responsible for heritable cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) syndrome with alterations in vascular smooth muscle cells (VSMCs) [22]. This evidence concerns the gene NOTCH3 and cerebral arteriopathy with subcortical infarcts and leukoencephalopathy.