While well controlled IL-6 expression plays a critical role in maintaining the homeostasis of skeletal muscles, studies also showed that persistent Tyr705 phosphorylation is associated with impairment of metabolism by negatively affecting skeletal muscle insulin signaling and glucose uptake [37] and is believed to be responsible for the IL-6-induced cancer cachexia [33, 38]. The gene discussed is INS; the disease is Cachexia.