Likewise, substitution mutation within the seed region of MIR184 has also been mapped in patients with endothelial dystrophy, iris hypoplasia, congenital cataract, and stromal thinning, not associated with keratoconus (EDICT syndrome) [38, 43] as well as familial KC with cataract [14]. Here, MIR184 is linked to corneal endothelial dystrophy.