More recent classifications, which divide medulloblastomas into four molecular subgroups [WNT, Sonic Hedgehog (SHH), Group 3 and Group 4] show that tumors with genomic alterations in SHH and WNT signaling pathways overall had better prognosis than Groups 3 and 4 medulloblastomas (4–7). The gene discussed is SHH; the disease is medulloblastoma.