Northcott et al. recently showed that overexpression of GFI1 or GFI1B, associated with genomic lesions (duplication, breakpoints) around 1p22 and 9q34, respectively, act as oncogenes cooperating with MYC in Group 3 and Group 4 medulloblastomas (38). The gene discussed is GFI1; the disease is medulloblastoma.