Thrombocytosis can result in thrombosis and is frequently observed in patients with malignancies The mechanism underlying development of thrombocytosis in lung cancer patients remains unclear; one of possible mechanisms might be tumor-associated elevation of bone marrow-stimulating cytokines such as interleukin (IL)-6, IL-1 and macrophage colony stimulating factor (M-CSF). The gene discussed is CSF1; the disease is Thrombocytosis.