In our study, in sham group, MAP-2(+) cells showed staining mainly in the dendrites of the cells; in ischemic animals, we examined the expression of MAP-2 in peri-infarct area at 3 d, 7 d, and 14 d after MCAO; the level of MAP-2 markedly decreased compared to sham group and persistently increased from 3 d to 14 d after stroke, which was consistent with previous study [48]. The gene discussed is MAP2; the disease is stroke disorder.