A recent study has suggested that inhibition of Bcl2/Bax ratio may be a novel target for the treatment of stroke [39], and these authors have shown that chemokine-like factor 1 (CKLF1), a novel C-C chemokine, with antibodies displays neuroprotective effects against cerebral ischemia via regulation of apoptosis-related protein expression in ischemic hemisphere. This evidence concerns the gene BCL2 and brain ischemia.