Such studies emphasize the importance of MC-derived histamine, CXCL1/GRO-α, CXCL10/IP-10, and CXCL8/IL-8 in TC as essential factors for tumor proliferation and invasion and for the induction and maintenance of the mesenchymal and stem-like phenotype of aggressive, metastatic TC cells (Figure 1). This evidence concerns the gene CXCL1 and neoplasm.