HMGB1 and kidney disorder: Identified substrates include GLP-1, regulated on activation, normal T cell expressed and secreted (RANTES), which is relevant in renal disease (3, 4), brain natriuretic peptide 1–32 (5, 6), neuropeptide Y (7), high mobility group protein 1 (HMGB1) (8), and Substance P (9).