The mutant mice with epidermal deletion [by K5 (or K14)-Cre-mediated deletion of a floxed gene] of JunB (transcription factor) (17), a disintegrin and metalloproteinase 17 (ADAM17) (18, 19) or Notch receptors/their signal transducers (20) exhibited both AD-like skin inflammation and MPN. This evidence concerns the gene ADAM17 and myeloproliferative neoplasm.