Consistent with the role of reduced EGFR signaling in AD-like skin inflammation in Adam17fl/fl;K14-Cre mice, an ADAM17-targeted EGFR ligand transforming growth factor-α, whose expression was strongly reduced in Adam17−/−keratinocytes, could reconstitute the skin barrier function in Adam17−/− mice, and mice with epidermal deletion of EGFR exhibited AD-like dermatitis just like Adam17fl/fl;K14-Cre mice (19). This evidence concerns the gene ADAM17 and Alzheimer disease.