The 10 most significant cytokines for delineating HPS in decreasing order of importance are: M-CSF, CXCL16, sCD40, CXCL12, CCL22, IL-1a, CCL21, IL-12p40, CCL17, and IL-1b. This evidence concerns the gene CXCL16 and Hermansky-Pudlak syndrome.