Inhibition of both RhoA and Rac1 GTPases resulted in 48 ± 2% decrease in HIV-1 RT activity, when inhibitors were applied prior to HIV-1 infection of MDM (Figure 4A), whereas post-infection treatment with Rho GTPase inhibitors led to 85 ± 3% diminution in HIV-1 RT (Figure 4B). Here, RAC1 is linked to HIV-1 infection.