A similar difference in also observed for 2Apro, where the appearance of eIF4G cleavage products (as a proxy for detecting 2Apro directly) was observed from 3 h.p.i in HRV2 infection, while for HRV16 infection these cleavage products were observed from 6 h.p.i. In addition, the rate of eIF4G cleavage appeared to be faster in HRV2 infection, with only 4% of full length eIF4G remaining at 9 h.p.i, while 26% of full length eIF4G still remained at 24 h.p.i after HRV16 infection. Here, EIF4G1 is linked to infection.