KHDRBS1 and infection: The mislocalization of Sam68 and alteration in the appearance of SC35 occurred as an early event during infection with both HRV2 and HRV16, before there was significant disruption of nuclear pore components in either HRV2 or HRV16 infection, suggesting that either a very small amount of viral protease activity is required to initiate these changes, or that early infection events prompt an additional pathway that contributes to the observed changes.