Interestingly, a recent study reported that serum FGF21 levels are independently associated with acute myocardial infarction (54), showing that serum FGF21 levels are markedly increased on the first day after the onset of myocardial infarction and remain high on days 3 and 7; moreover, FGF21 levels were found to be closely related to those of brain natriuretic protein (BNP), a common marker of cardiac diseases. Here, NPPB is linked to myocardial infarction.