Moreover, FGF21 deletion in mice exacerbates diabetic cardiomyopathy by aggravating cardiac lipid accumulation, although it is not clear whether this is a direct effect of the lack of FGF21 action on heart or indirect due to altered systemic lipid homeostasis in diabetic FGF21-null mice (31). Here, FGF21 is linked to diabetic cardiomyopathy.