Forty-nine patients of clinically characterized diagnosis were included for the protein-array analysis: the cohort was composed of individuals with pre-symptomatic (MCI, mild cognitive impairment, n = 20) or late-stage AD (n = 14) patients and from control subjects (n = 15), Figure 1A. MMSE differed between the groups and was, as expected, significantly correlated with Aβ42, Tau or p-Tau (p < 0.001, “Spearman” rank correlation). Here, MAPT is linked to Cognitive impairment.