The major findings of this study are as follows: (i) HEX is a potential organic nitrate able to release NO and promote relaxation through the activation of the sGC/GMPc/PKG pathway and KATP channels; (ii) HEX promotes hypotension in normotensive and hypertensive animals; (iii) oral administration of HEX for 7 days induces antihypertensive effect in renovascular hypertensive animals. This evidence concerns the gene PRKG1 and hypertensive disorder.