TNNI3 and familial dilated cardiomyopathy: In fact, blunting or abolishing of Ca2+ desensitization induced by cTnI phosphorylation appears to be a common feature among mutations in cTnC linked to DCM in human patients (with an exception of the D145E mutation) studied to date (Biesiadecki et al., 2007; Pinto et al., 2011).