Similarly, fractional sarcomere shortening was not reduced in myocytes isolated from heterozygous knock-in mice harboring the DCM-linked ΔK210 mutation in cTnT (heterozygous ΔK210cTnT mice), despite reduced Ca2+ sensitivity of force development observed in these mice (Du et al., 2007). Here, TNNT2 is linked to familial dilated cardiomyopathy.