The phenotype of the D73N (+/−) mice resembled that of homozygous knock-in mice harboring the DCM-linked ΔK210 mutation in cTnT (homozygous ΔK210cTnT mice) (Du et al., 2007; Sugihara et al., 2013). Here, TNNT2 is linked to familial dilated cardiomyopathy.