Many of the anti-inflammatory genes in Table 3 are not directly associated with PAD or CAD based on PubMed search, such as ADORA2B (adenosine A2b receptor), EDNRA (endothelin receptor type A), FCER1G (Fc receptor, IgE, high affinity I, gamma polypeptide), STAT5B (signal transducer and activator of transcription 5B), and TLR9 (toll-like receptor 9). The gene discussed is IGHE; the disease is peripheral arterial disease.