A MsrA (methionine sulfoxide reductase) knockout with higher levels of ox-CaMKII was showing dramatically reduced survival 30 days after myocardial infarction (Erickson et al., 2008) whereas MsrA overexpression seemed to be cardioprotective (He et al., 2011; Purohit et al., 2013). The gene discussed is CAMK2G; the disease is myocardial infarction.