Here, we measured serum levels of BDNF in AD patients and found that a GO game increased serum BDNF levels in SGGI and LGGI groups (24.02 ± 7.16 and 28.88 ± 4.12 ng/ml respectively, t = 0.345, P = 0.051) compared those in controls (17.28 ± 7.75 ng/ml) (t = 3.423, P = 0.001) after 6-month follow-up. This evidence concerns the gene BDNF and Alzheimer disease.