Intriguingly, both the marginal zone and subplate have been shown to highly express some of the genes most significantly linked to neurodevelopmental disorders such as autism and schizophrenia, such as Reelin and TBR1 (Hevner et al., 2001; Bielle et al., 2005; Hoerder-Suabedissen et al., 2013). This evidence concerns the gene RELN and neurodevelopmental disorder.