Ago2 has been shown to interact with the QKI-6 RNA binding protein in stress conditions in cytoplasmic granules and in turn QKI-6 colocalizes with Mbp mRNA in stress granules of U343 human glioblastoma cells, but an involvement of the miRISC was not suggested (Wang et al., 2010). The gene discussed is AGO2; the disease is glioblastoma.