Interestingly, APP and tau transcripts are upregulated and regulators of APP metabolism (BACE1, PSEN1, PSEN2) and tau phosphorylation (MARK1/3/4, CDK5, PINK1) are downregulated in memory-related brain regions in individuals with moderate and clinical diagnosis of AD (Liang et al., 2010). This evidence concerns the gene PSEN1 and Alzheimer disease.