Gating changes permitting enhanced Ca2+ inward current through Cav1.3 were not only identified as cause for excessive aldosterone secretion in adrenal adenomas (Azizan et al., 2013) but also as cause for PASNA, a severe human congenital disease (Scholl et al., 2013) and as high risk de novo mutations for autism with intellectual disability (Pinggera et al., 2015). Here, CACNA1D is linked to Intellectual disability.