Mutations enhancing Cav1.3 activity were discovered in patients with a severe congenital multiorgan syndrome with primary aldosteronism, seizures and neurologic abnormalities including global developmental delay and intellectual disability (PASNA, OMIM #615474) (Azizan et al., 2013; Scholl et al., 2013). The gene discussed is CACNA1D; the disease is aldosterone-producing adenoma with seizures and neurological abnormalities.