Interestingly, acute and short-term administration of Sildenafil improves endothelial function in men with Type 2 diabetes [35], whereas chronic administration of Sildenafil, besides significantly improving endothelial function, can also reduce inflammatory markers (nitrite/nitrate levels, C-reactive protein, IL-6, ICAM-1 and VCAM-1) in patients with Type 2 diabetes [36]. Here, VCAM1 is linked to type 2 diabetes mellitus.