PDE5A and benign prostatic hyperplasia: Similarly, a recent systematic review and network meta-analysis comparing the effectiveness of oral drug therapies for BPH/LUTS revealed that of all the available drug treatments, combination therapy with α1-adrenoceptor antagonists and PDE5 inhibitor ranked highest in efficacy for decreasing the International Prostate Symptom Score (IPSS) total score, storage subscore and voiding subscore.