HOTAIR and metastatic malignant neoplasm in the lymph nodes: A meta-analysis demonstrated that HOTAIR expression was a significant factor in the incidence of lymph node metastasis (present versus absent: OR 4.47, 95% CI: 1.88–10.63) and vessel invasion (positive versus negative: OR 2.88, 95% CI: 1.38–6.04) without heterogeneity across studies [115]. In vitro, inhibition of HOTAIR in gastric cancer cells suppresses tumor invasion and reverses epithelial-to-mesenchymal transition [116].