CHI3L1 and hydrops fetalis: ELISA for CHI3L1 detection was performed on end-diet plasma samples of the same CTRL and HF animals and the circulatory expression of the protein resulted as 2.6 ± 0.4 ng/mL in CTRL samples (mean ± SD) and 12.4 ± 3.5 ng/mL in HF samples (mean ± SD) (P value = 0.001).