Among the most downregulated mRNAs in Y79 cells, ACOT7 and DLL3 represent novel therapeutic targets for future retinoblastoma studies, which we found to be expressed in primary retinoblastomas and retinas (Fig 8 and S9 Fig), and overexpressed in retinoblastoma cell lines as compared to normal retinas (S8 Fig). The gene discussed is DLL3; the disease is retinoblastoma.