The importance of iNOS to immune defense is reflected by the fact that iNOS-deficient mice are susceptible to sublethal LVS infections [9], and chemical inhibition of iNOS activity significantly inhibits IFN-γ-induced killing of LVS and virulent F. tularensis in peritoneal exudate macrophages in vitro [10, 11]. The gene discussed is NOS2; the disease is infection.