IFNB1 and glioblastoma: For example, we recently reported that BV6 synergizes with IFNα to trigger apoptosis in acute myeloid leukemia cells.22 Of note, BV6 was found in the present study to transcriptionally upregulate IFNβ, but not IFNα in glioblastoma cells, pointing to distinct roles of type I IFNs in this context.