Type I IFNs such as IFNα and IFNβ have been reported to synergize with TMZ in cell death induction in glioblastoma cells.16, 17 Therefore, we analyzed mRNA expression levels of IFNα and IFNβ upon treatment with BV6 and/or TMZ using quantitative real-time-PCR (qRT-PCR) analysis, as IFNs were not represented on the expression bead chip hybridization assay. The gene discussed is IFNA1; the disease is glioblastoma.