In relevance to human breast cancer, methylations in CG rich region of p53 promoter impaired its transcription and protein levels,8 and impaired expression of the transcriptional factor HOXA5 also decreased p53 mRNA level in the tumor tissues.9 All these implied the importance of p53 expression and its regulatory mechanisms for stress responses and tumor suppression. The gene discussed is TP53; the disease is neoplasm.