In the present study we demonstrate tumor growth suppression and complete inhibition of metastasis by apigenin intake are associated with inhibition of DNA binding activity of NF-κB/p65, IκBα degradation, IκBα phosphorylation, IKK activation and NF-κB-dependent gene expression in the dorsolateral prostate of TRAMP mice. This evidence concerns the gene NFKB1 and neoplasm.