Studies have reported that NF-κB is constitutively activated in human prostate cancer tissue, androgen-refractory human prostate carcinoma cells, prostate tumor xenografts and in the prostate of the transgenic adenocarcinoma of the mouse prostate (TRAMP) model, which emulates progressive forms of human prostate cancer [17–20]. This evidence concerns the gene NFKB1 and Familial prostate cancer.