BAX and cancer: In addition, apigenin has been shown to induce apoptosis in a variety of cancer cells including breast, melanoma, thyroid, skin, hepatoma, prostate carcinoma and lymphoma, acute myelogeous leukemia [31–37], through inhibition of DNA replication, caspase activation, perturbance in cell cycle regulatory molecules, inhibition of protein kinases, generation of reactive oxygen species, mitochondrial damage and interference in Ku70-Bax interaction [38–41].