NOS2 and neoplasm: Phosphorylation of p65/RelA facilitates its binding to a specific sequence in DNA, which triggers the transcriptional activation of NF-κB-regulated genes including, anti-apoptotic genes (cIAP, survivin, Bcl2, and BCl-xL), cell cycle-regulatory genes (cyclin D1), genes encoding adhesion molecules, chemokines, inflammatory cytokines, pro-angiogenic gene, vascular endothelial growth factor (VEGF), and genes involved in tumor metastasis such as cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and matrix metalloproteinase-9 (MMP-9) [8, 9].