Previous studies did not always indicate a direct correlation between TRAIL receptor expression and TRAIL mediated apoptosis in tumor models[15, 23, 24] since other factors such as the expression levels and activities of NFkB and BCL-2 also play important roles in bortezomib resistance[25–27] as well as TRAIL mediated apoptosis[12, 28, 29]. Here, BCL2 is linked to neoplasm.