We next determined changes in the cell surface expression levels of the pro-apoptotic receptors TRAIL-R1 and R2, as well as the anti-apoptotic decoy receptors TRAIL-R3 and R4 upon in vitro bortezomib treatment in MM cells with or without del(8)(p21) (Fig 3). Here, TNFRSF10A is linked to Miyoshi myopathy.