While the alteration of cell surface TRAIL receptor expression due to del(8)(p21) might cause decreased sensitivity of tumor cells to TRAIL-mediated apoptosis[11] [12], it must be noted that these clones still carry one copy of each TRAIL-R gene, since the deletion in the 8p21 region is almost exclusively monoallelic. The gene discussed is TNFSF10; the disease is neoplasm.