However, in mice that were treated with DAA-I for 14 days before and 15 days after TBI, significant recovery of the four myelodysplastic syndromes were observed (Fig 2).TBI also caused an increase in circulating IL-6 and TNF-α in surviving mice, and DAA-I attenuated the increase of both the inflammatory cytokines (Fig 3). Here, IL6 is linked to myelodysplastic syndrome.