MDM2 and ependymoma: Interestingly, in other publicly available glioma datasets including pediatric high-grade gliomas [21], DIPGs [22] and ependymomas [23], such correlations with MDM2 expression do not exist, with very few genes passing the same false discovery rate criteria (FDR < 0.001) although this might be partially explained by PAs being very homogeneous entities whereas other tumor types are mixtures of multiple subgroups (Supplementary Figure 2a–2c).