IMPA1 and cancer: Ivermectin, on the other hand, is a potent inhibitor of importin α/β (Impα/β1) nuclear import dependent transport, with no effect on proteins containing nuclear localization signal (NLSs) recognized by alternative nuclear import pathways [19] Incubation of cancer cell lines with Ivermectin resulted in decreased expression of LC3s and Beclin-1 in the nuclei, a result however that varied among cell lines and proteins examined.