For instance, the survival rates of non-small-cell lung cancer (NSCLCs) patients with EGFR mutations were improved by first-generation epidermal growth factor receptor (EGFR) kinase inhibitors, gefitinib and erlotinib; however, 50% of these patients will acquire resistance and ultimately relapse due to a second mutation on EGFR (T790M) [36, 37]. Here, EGFR is linked to non-small cell lung carcinoma.