To evaluate the clinical relevance of SOSTDC1 in thyroid cancer, we investigated the SOSTDC1 protein expression in 16 cases of goiters, 15 cases of adenomas, and 107 cases of thyroid cancers (26 cases FTC, 69 cases PTC, and 12 cases ATC) by immunohistochemistry. The gene discussed is SOSTDC1; the disease is goiter.