For example, it was previously indicated that SOSTDC1 is significantly down-regulated in clear cell renal carcinoma and over-expression of SOSTDC1 inhibits its proliferation through suppressing BMP-7-induced phosphorylation of Smad-1, -5, and -8, as well as Wnt-3a signaling [10]. Here, SOSTDC1 is linked to clear cell renal carcinoma.