SETDB2 and asthma: SETDB2 is transcribed in the same direction as PHF11 and cotranscripts extending from SETDB2 to PHF11 exist in many human tissues.2 Owing to the small intervening distance and the LD structure between these genes, it is not currently possible to delineate the relative roles of SETDB2 and PHF11 in asthma and its associated traits.