Chromosome 13q was first shown to associate with asthma-related traits by whole-genome linkage analysis in 1996.14 Subsequently, the genes PHF11 and SETDB2 were implicated by positional cloning of the locus.2, 15 Our earlier genetic analyses had indicated that variation in total serum IgE levels was attributable, at least in part, to variation in the PHF11 gene on chromosome 13q14. The gene discussed is IGHE; the disease is asthma.