HCC recurrence, metastasis and prognosis are also predicted by altered lncRNAs including GAS5 (growth arrest-specific transcript 5), HEIH (high expression in HCC), HOTAIR, HOTTIP (HOXA transcript at the distal tip), MALAT1 and UCA1 [23,28,30,31,32,33]. The gene discussed is HOTAIR; the disease is hepatocellular carcinoma.