including two markers first identified in HCC—Kcnq1ot1 (KCNQ1 overlapping transcript 1), a well-characterized tumor suppressor [37] and NRON [noncoding repressor of NFAT (nuclear factor of activated T-cells)] [38] to repress NFAT functions involved in carcinogenesis, cancer cell proliferation and metastasis [39,40]. The gene discussed is NRON; the disease is cancer.