The aims of this study were: (1) to analyze differences in miRNA expression profiles between BRCA1/2-associated breast carcinomas, normal breast tissue from BRCA1 and BRCA2 germ-line mutation carriers, and normal breast tissue from non-mutation carriers; (2) to obtain more insight into BRCA1/2-associated carcinogenesis by identification of target genes and pathways regulated by miRNAs. This evidence concerns the gene BRCA2 and breast carcinoma.