These miRNAs, which might distinguish BRCA1 and BRCA2 germ-line carriers with a higher risk from those with a lower risk of developing breast cancer, are involved in pathways such as integrin signaling, estrogen receptor signaling, breast cancer regulation by Stathmin1, HIF1α Signaling, Wnt/β-catenin Signaling, and p53 signaling (IPA analysis). This evidence concerns the gene HIF1A and breast cancer.