The patient samples (all FFPE) consisted of 5 classes: BRCA1-associated breast carcinomas (BRCA1-C) (n = 17); BRCA2-associated breast carcinomas (BRCA2-C) (n = 9); normal breast tissue from BRCA1 germ-line mutation carriers (BRCA1-N) (n = 5) and BRCA2 germ-line mutation carriers (BRCA2-N) (n = 5), both derived from prophylactic mastectomies; and normal breast tissue from non-mutation carriers derived from mammoplasty specimens (healthy-N) (n = 10). This evidence concerns the gene BRCA2 and breast carcinoma.