These include activation of the tumor suppressor, protein phosphatase 2A or inhibition of leukemia stem cell self-renewal by targeting the Wnt/β-catenin pathway through inhibition of MAP kinase interacting serine/threonine kinase (MNK)-eukaryotic translation initiation factor 4E (eIF4E) axis [3, 4]. The gene discussed is EIF4E; the disease is leukemia.